It depends on the amp. If it’s not truly balanced amp, stick with regular trs and save the cash.
Schiit Jotunheim, it makes a difference. Eddy Current Black Widow 2, no difference. The ifi thingy… no clue if the balanced connection is there for convenience (which is what I suspect), or if they’re running truly balanced (doubt it), or doing some hybriy trickery and slapping the marketing fluff “S-Balanced” term on it just to sell more units (my second pick).